What is a preferred antihistamine for managing allergic rhinitis?

The preferred antihistamine for managing allergic rhinitis is cetirizine. This second-generation antihistamine is specifically designed to relieve symptoms associated with allergic rhinitis, such as sneezing, runny nose, and itching, with minimal sedative effects compared to first-generation antihistamines.

Cetirizine operates by selectively blocking peripheral H1 receptors, which helps reduce the symptoms of allergens without penetrating the central nervous system to a significant degree, thereby limiting sedation. This is particularly advantageous for patients who need to remain alert and functional, such as those involved in work or daily activities.

In contrast, first-generation antihistamines like chlorpheniramine and diphenhydramine are more likely to cause sedation and may not be as effective or preferred for long-term use in managing allergic rhinitis. Phenylephrine, while it is a decongestant, does not address the histamine-mediated symptoms that are central to allergic rhinitis. This distinct action of cetirizine positions it as the more effective choice for treating this specific condition.