In a 16-year-old female with mild acne, which treatment option is the least appropriate?

In the context of treating mild acne, oral doxycycline is considered the least appropriate treatment option for a 16-year-old female. While doxycycline is an effective oral antibiotic used for moderate to severe cases of acne, it is typically not the first-line treatment for mild acne. Guideline recommendations favor topical treatments over systemic treatments for mild conditions, as they are effective, have fewer side effects, and lower the risk of antibiotic resistance.

Benzoyl peroxide is an effective over-the-counter topical agent known for its antibacterial and keratolytic properties, making it suitable for mild acne. Topical clindamycin is also a widely used antibiotic that targets acne-causing bacteria when applied directly to the skin. Adapalene, a topical retinoid, is effective for acne treatment by promoting cell turnover and preventing clogged pores.

In summary, oral doxycycline is more appropriate for moderate to severe acne, whereas the other options represent first-line topical therapies that are better suited for mild acne in adolescents.